王建华，男，博士，教授，博士生导师
广州黄埔杰出人才
中科院“百人计划”
中科院特聘教授
中国科学院大学客座教授
E-mail：jh_wang@sibs.ac.cn
教育经历：
1995.09—1999.07 河南大学 生物学
1999.09—2005.07 中国科学院昆明动物研究所 病毒学
工作经历：
2005.09—2009.03 美国威斯康星州医学院 博士后
2009.03—2020.03 中国科学院上海巴斯德研究所 研究员
2020.03—2025.02 中国科学院广州生物医药与健康研究院 研究员
2025.03—至今 抗病毒性传染病创新药物全国重点实验室 教授
研究领域与兴趣：
聚焦病毒性传染病关键科学问题，开展病毒致病机制、干预靶点发现和创新药物研发。包括，针对艾滋病病毒（HIV）潜伏根治缺乏治疗靶点这一科学难题，阐述HIV潜伏维持和重激活的宿主动态调控机制，鉴定起关键调控作用的宿主因子和细胞信号通路，为HIV潜伏根治提供潜在靶点;针对重要传染病病原，建立成药性评价体系，开展抗病毒创新药物研发。
近年来主持的主要科研项目：
1.国家自然科学基金面上，82172242, 从新型冠状病毒诱导肥大细胞脱颗粒揭示炎症反应产生的细胞学机制及免疫调节剂的研发，2022/01-2025/12，直接经费55万，主持
2.呼吸疾病国家重点实验室开放课题，SKLRD-OP-2022207, 新冠状病毒通过诱导肥大细胞脱颗粒增强肺微血管通透性的细胞学机制，2022/01-2024/12， 20万，联合主持
3.广东省自然科学基金面上项目，2022A1515012053，从新冠病毒诱导肥大细胞脱颗粒炎症揭示病毒诱导肺损伤的细胞免疫学机制，2022/01-2024/12，10万，主持
4.中国科学院前沿科学重点研究项目，QYZDB-SSW-SMC059，艾滋病病毒潜伏感染机制及治疗策略研究，2017/5-2022/12，250万，主持；
5.国家自然科学基金面上，81873965，HIV潜伏感染人源化小鼠模型的建立及在潜伏激活剂功能评价中的应用，2019/01-2022/12，直接经费80万，主持
6.科技部艾滋病和病毒性肝炎重大传染病专项，2018ZX10301101，HIV病毒潜伏库清除新策略研究。2018/01-2020/12, 183.74万，参与；
7.中国科学院科研装备研制项目, 细胞三维超分辨实时显微成像系统, 2017/01-2018/12, 联合申请，承担70万（项目共298万）；
8.中国科学院分子病毒与免疫重点实验室开放基金，人内源性逆转录病毒的免疫应答， 2017/01-2017/12，6万，联合主持；
9.国家自然科学基金-NIH联合项目，81561128009，HIV-1 Nef蛋白与宿主蛋白Naf1相互作用调控病毒潜伏感染, 2016/01-2018/12，直接经费250万, 主持；
10.国家自然科学基金面上，81572001，宿主因子Tollip抑制HIV-1转录及调控病毒潜伏感染的分子机制研究，2016/01-2019/12，直接经费50万, 主持；
11.科技部艾滋病和病毒性肝炎重大传染病专项，2014ZX10001003-003，宿主因子靶向敲除与造血干细胞遗传改造平台的建立，2014/01- 2016/12，139万，子课题负责人；
12.中科院交叉创新团队人才基金，利用机器人化三维拾取技术监测病毒对宿主细胞的感染， 2013/01-2015/12，100万，已结题，首席；
13.国家重点基础研究发展计划（973计划），2012CB519004，重要病毒持续性感染形成和维持的分子机制研究，2012/1-2016/12，70万，已结题，子课题参与；
14.国家自然科学基金面上项目，81171567，真菌诱导树突状细胞的激活增强其介导HIV-1感染T细胞的机制研究，2012/01-2015/12，58万，已结题，主持；
15.中科院病毒免疫重点实验室开放基金，2012-2014，5万，已结题，共同主持；
16.上海市启明星计划项目，11QA1407700，从HIV对TLR信号通路的挟持或利用分析树突状细胞介导病毒感染的分子机制，2011/1-2013/12，15万，结题，主持；
17.中科院优秀青年人才项目，KSCX2-EW-Q-2, 真菌刺激树突状细胞的免疫激活与HIV-1的致病机理研究，2011/1-2013/12，80万，结题，主持；
18.中国科学院百人计划项目，KSCX2-KW-BR-1，HIV-1与树突状细胞的相互作用及病毒的致病机理，2010/01-2012/12，200万，结题，主持；
19.上海市自然科学基金面上项目，10ZR1435200, MHC-Ⅱ分子在DC介导HIV-1感染T细胞中的作用研究, 2010/04-2012/03,10万，已结题，主持。
20.病毒学国家重点实验室开放基金，2010011，树突状细胞介导HIV-1感染T细胞的分子机制，2010/3-2011/2，3万，已结题，共同主持；
21.中科院疫苗网络项目，KSCX2-YW-R-210，基于树突状细胞的HIV-VLP疫苗的免疫策略，2009-2010，30万，已结题，子课题负责人；
22.中科院上海生命科学研究院优秀青年人才项目，2009KIP209，树突状细胞介导HIV感染CD4+T细胞的分子机制，2009-2011，21万，结题，主持。
获得荣誉：
2023，《Journal of Leukocyte Biology》,Editor (2023-2025)
2022, 《Frontiers in Cellular and Infection Microbiology》,Associated Editor
2021, 广州黄埔杰出人才
2020，《生命的化学》杂志编委（2020.6-2024.5）
2018, 《Virology Journal》， Section Editor;
2017，《Virologica Sinica》杂志编委；
2016，上海市科技系统青年五四奖章；
2015，中国科学院大学岗位教授；
2013，中科院“朱李月华优秀教师奖”；
2011，上海市启明星计划（A 类）；
2010，赛诺菲-安万特-中国科学院上海生命科学研究院优秀青年人才奖；
2010，中科院“百人计划”。
代表性论文：
1. Shuang Zhang, Chu-Lan Xu, Jing-Jing Wang, Xiao-Li Xiong, Jian-Hua Wang*. Spike proteins of coronaviruses activate mast cells for degranulation via stimulating Src/PI3K/AKT/Ca2+ intracellular signaling cascade. J Virol. 2025, Accepted.
2. Tian-Jiao Fan, Chengzuo Xie, Xia Jin, Jie Cui, Jian-Hua Wang. HIV-1 Nef activates proviral DNA transcription via recruiting Src kinase to phosphorylate host protein Nef-associated factor 1 to compromise its viral restrictive function. J Virol. 2025, Accepted.
3. Chengzuo Xie, Xia Jin, Wan-Wei Li*, Jian-Hua Wang*. Host factor Naf1 restricts HIV-1 infection of myeloid cells and compromises the capacity of dendritic cell to prime CD4+ T cell. Virol Sin. 2025, online.
4. Wu ML, Xie C, Li X, Sun J, Zhao J, Wang JH. Mast cell activation triggered by SARS-CoV-2 causes inflammation in brain microvascular endothelial cells and microglia. Front Cell Infect Microbiol. 2024. PMCID: 38638822.
5. Cao JB, Zhu ST, Huang XS, Wang XY, Wu ML, Li X, Liu FL, Chen L, Zheng YT, Wang JH. Mast cell degranulation-triggered by SARS-CoV-2 induces tracheal-bronchial epithelial inflammation and injury. Virol Sin. 2024. PMID: 38458399.
6. Hou J, Peng Y, Liu B, Zhang Q, Wang JH, Yu W, Chang J. 4'-Ethynyl-2'-deoxy-2'-β-fluoro-2-fluoroadenosine: A Highly Potent and Orally Available Clinical Candidate for the Treatment of HIV-1 Infection. J Med Chem. 2023. PMID: 37535016.
7. Huang X, Fan W, Sun J, Yang J, Zhang Y, Wang Q, Li P, Zhang Y, Zhang S, Li H, Wang J, Feng L, Zhao J, Chen L, Qu L. SARS-CoV-2 induces cardiomyocyte apoptosis and inflammation but can be ameliorated by ACE inhibitor Captopril. Antiviral Res. 2023. PMID: 37207821.
8. Jia J, Zhao Y, Wang JH, Kuang YQ. Isolating peripheral blood mononuclear cells from HIV-infected patients for single-cell RNA sequencing and integration analysis. STAR Protoc. 2023. PMID: 37060557.
9. Song S, Lin Z, Zhao C, Wen J, Chen J, Xie S, Qi H, Wang J, Su X. Vagal-mAChR4 signaling promotes Friend virus complex (FV)-induced acute erythroleukemia. Virol Sin. 2023. PMID: 37172825.
10. Qin J, Hu B, Song Q, Wang R, Zhang X, Yu Y, Wang JH. The transmembrane replacement H7N9-VLP vaccine displays high levels of protection in mice. Front Microbiol. 2022. PMID: 36274725.
11. Jia J, Zhao Y, Yang JQ, Lu DF, Zhang XL, Mao JH, Wang KH, Wang JH, Kuang YQ. Naïve B cells with low differentiation improve the immune reconstitution of HIV-infected patients. iScience. 2022. PMID: 36465118
12. Han J, Zhou YH, Ma Y, Zhu G, Zhang D, Zhu B, Cheng T, Wang L, Wang JH, Li L, Zhang C. A New HIV-1 K28E32-Reverse Transcriptase Variant Associated with the Rapid Expansion of CRF07_BC among Men Who Have Sex with Men. Microbiol Spectr. 2022. PMID: 36214682.
13. Wu ML, Liu FL, Sun J, Li X, Qin JR, Yan QH, Jin X, Chen XW, Zheng YT*, Zhao JC*, Wang JH*. Combinational benefit of antihistamines and remdesivir for reducing SARS-CoV-2 replication and alleviating inflammation-induced lung injury in mice. Zoological Research. 2022. PMID: 35503561
14. Song ST, Wu ML, Zhang HJ, Su X*, Wang JH*. Mast Cell Activation Triggered by Retrovirus Promotes Acute Viral Infection. Front. Microbiol. 2022. PMID: 35197951.
15. Wen J, Li X, Zhao QX, Yang XF, Wu ML, Yan Q, Chang J, Wang H, Jin X, Su X, Deng K, Chen L, Wang JH*. Pharmacological suppression of glycogen synthase kinase-3 reactivates HIV-1 from latency via activating Wnt/β-catenin/TCF1 axis in CD4 + T cells. Emerg Microbe Infect. 2022. PMID: 34985411.
16. Wen J, Zhao C, Chen J, Song S, Lin Z, Xie S, Qi H, Wang J, Su X. Activation of α7 nicotinic acetylcholine receptor promotes HIV-1 transcription. Cell Insight. 2022. PMID: 37193048.
17. Yu Y, Wan Z, Wang JH, Yang X, Zhang C. Review of human pegivirus: Prevalence, transmission, pathogenesis, and clinical implication. Virulence. 2022. PMID: 35132924.
18. Shi X, Yang Y, Zhang X, Chang X, Chen J, Wang C, Wang A, Wang J, Qin J, Ye X, Jin W, Zhang G. miR-541-3p Promoted Porcine Reproductive and Respiratory Syndrome Virus 2 (PRRSV-2) Replication by Targeting Interferon Regulatory Factor 7. Viruses. 2022. PMID: 35062330.
19. Dong Y, Wan Z, Li S, Wang JH, Jin X, Yu G, Zhang C. Genomic phylogenetic analyses of four major hand, foot and mouth disease-related enteroviruses. Acta Virol. 2022. PMID: 35380863.
20. Wu ML, Liu FL, Sun J, Li X, He XY, Zheng HY, Zhou YH, Yan Q, Chen L, Yu GY, Chang J, Jin X, Zhao J, Chen XW*, Zheng YT*, Wang JH*. SARS-CoV-2-triggered mast cell rapid degranulation induces alveolar epithelial inflammation and lung injury. Sig Transduct Target Ther. 2021. PMID: 34921131
21. Li T, Yang Y, Li Y, Wang Z, Ma F, Luo R, Xu X, Zhou G, Wang J, Niu J, Lv G, Crispe IN, Tu Z. Platelets mediate inflammatory monocyte activation by SARS-CoV-2 Spike protein. J Clin Invest, 2021. PMID: 34964720
22. Yan Q, Li P, Ye X, Huang X, Feng B, Ji T, Chen Z, Li F, Zhang Y, Luo K, Chen F, Mo X, Wang J, Feng L, Hu F, Lei C, Qu L, Chen L. Longitudinal Peripheral Blood Transcriptional Analysis Reveals Molecular Signatures of Disease Progression in COVID-19 Patients. J Immunol. 2021. PMID: 33846224.
23. Sun L, Peng Y, Yu W, Zhang Y, Liang L, Song C, Hou J, Qiao Y, Wang Q, Chen J, Wu M, Zhang D, Li E, Han Z, Zhao Q, Jin X, Zhang B, Huang Z, Chai J*, Wang JH*, Chang J*. Mechanistic Insight into Antiretroviral Potency of 2'-Deoxy-2'-β-fluoro-4'-azidocytidine (FNC) with a Long-Lasting Effect on HIV-1 Prevention. J. Med. Chem. 2020. PMID: 32678592
24. Lyu T, Yue Y, Hsieh E, Han Y, Zhu T, Song X, Cao W, Lyu W, Wang J, Li T. HIV-1 CRF01_AE subtype and HIV-1 DNA level among patients with chronic HIV-1 infection: a correlation study. BMC Infect Dis, 2020, PMID: 31964364
25. Zuo L, Liu K, Liu H, Hu Y, Zhang Z, Qin J, Xu Q, Peng K, Jin X, Wang JH, Zhang C. Trend of HIV-1 drug resistance in China: A systematic review and meta-analysis of data accumulated over 17 years (2001-2017). EClinicalMedicine. 2020, PMID: 31922125.
26. Ma L, Jiang QA, Sun L, Yang X, Huang H, Jin X, Zhang C, Wang JH*. X-linked RNA-binding Motif Protein modulates HIV-1 infection of CD4+ T cells by maintaining the tri-methylation of histone H3 lysine 9 at the downstream region of the 5′ long terminal repeat of HIV proviral DNA. mBio, 2020, PMID: 32317327.
27. Xie L, Chen L, Zhong C, Yu T, Ju Z, Wang M, Xiong H, Zeng Y, Wang J, Hu H, Hou W, Feng Y. MxB impedes the NUP358-mediated HIV-1 pre-integration complex nuclear import and viral replication cooperatively with CPSF6. Retrovirology. 2020. PMID: 32600399.
28. Fan TJ, Sun L, Yang XG, Jin X, Sun WW*, Wang JH*. The Establishment of an in vivo HIV-1 Infection Model in Humanized B-NSG Mice. Virolocia Sinica, 2019. PMID: 31863357.
29. Zhou YH, Sun L, Chen J, Sun WW, Ma L, Han Y, Jin X, Zhao QX, Li T, Lu H, Qiu X*, Wang JH*. Tryptophan Metabolism Activates Aryl Hydrocarbon Receptor-Mediated Pathway to Promote HIV-1 Infection and Reactivation. mBio, 2019. PMID:31848275.
30. Qu D, Sun WW, Li L, Ma L, Sun L, Jin X, Li T*, Hou W*, Wang JH*. Long noncoding RNA MALAT1 releases epigenetic silencing of HIV-1 replication by displacing the polycomb repressive complex 2 from binding to the LTR promoter. Nucleic Acids Res, 2019, PMID: 30788509.
31. Li Y, Fu X, Ma J, Zhang J, Hu Y, Dong W, Wan Z, Li Q, Kuang YQ, Lan K, Jin X, Wang JH*, Zhang C*. Altered respiratory virome and serum cytokine profile associated with recurrent respiratory tract infections in children. Nat Commun, 2019, PMID:31123265
32. Sun WW, Jiao S, Sun L, Zhou Z, Jin X, Wang JH*.SUN2 modulates HIV-1 infection and latency through association with lamin A/C to maintain the repressive chromatin. mBio, 2018.PMID: 29717016.
33. Ma L, Sun L, Jin X, Xiong SD, Wang JH*.Scaffold attachment factor B suppresses HIV-1 infection of CD4+ cells by preventing binding of RNA polymerase II to HIV-1's long terminal repeat.J Bio. Chem. 2018. PMID: 29887524.
34. Ren XX, Ma L, Sun WW, Kuang WD, Li TS, Jin X, Wang JH*.Dendritic cells maturated by co-culturing with HIV-1 latently infected Jurkat T cells or stimulating with AIDS-associated pathogens secrete TNF-alpha to reactivate HIV-1 from latency.Virulence, 2017. PMID: 28762683
35. Kuang WD, Zhou YH, Zhong P, Zhang C, Wang JH*. Amino acids at positions 3, 168, and 169 are associated with the ability of Nef proteins from HIV-1 CRF01_AE to downmodulate CD4. J Med Virol. 2017. PMID: 28500742.
36. Li C, Wang HB, Kuang WD, Ren XX, Song ST, Zhu HZ, Li Q, Xu LR, Guo HJ, Wu L*, Wang JH*. Naf1 regulates HIV-1 latency by suppressing viral promoter-driven gene expression in primary CD4+ T cells. J Virol. 2016, PMID:27795436.
37. Jiang AP, Jiang JF, Wei JF, Guo MG, Qin Y, Guo QQ, Ma L, Liu BC, Wang X, Veazey RS, Ding YB*, Wang JH*.Human mucosal mast cells capture HIV-1 and mediate viral trans-infection of CD4+ T cells.J Virol. 2015.PMID:26719250
38. Jiang AP, Jiang JF, Guo MG, Jin YM, Li YY, Wang JH*. Human blood circulating basophils capture HIV-1 and mediate viral trans-infection of CD4+ T cells. J Virol. 2015. PMID:26018157；
39. Ren XX, Wang HB, Li C, Jiang JF, Xiong SD, Jin X, Wu L, Wang JH*. HIV-1 Nef-associated factor 1 enhances viral production by interacting with CRM1 to promote nuclear export of unspliced HIV-1 gag mRNA.J Bio. Chem. 2016.PMID:26733199
40. Qian YW, Li C, Jiang AP, Ge S, Gu P, Fan X, Li TS, Jin X, Wang JH*, Wang ZL*. HIV-1 gp120 glycoprotein interacting with dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) down-regulates tight junction proteins to disrupt the blood retinal barrier and increase its permeability. J Bio. Chem. 2016. PMID: 27605665.
41. Shen CJ, Jia YH, Tian RR, Ding M, Zhang C, Wang JH*. Translation of Pur-α is targeted by cellular miRNAs to modulate the differentiation-dependent susceptibility of monocytes to HIV-1 infection. FASEB J, 2012;PMID 22835829.
42. Ren XX, Li C, Xiong SD, Huang Z, Wang JH*, Wang HB*. Antibodies to P-selectin glycoprotein ligand-1 block dendritic cell-mediated enterovirus 71 transmission and prevent virus-induced cells death. Virulence. 2015. PMID: 26399965.
43. Zhang Y, Li SK, Yi Yang K, Liu M, Lee N, Tang X, Wang H, Liu L, Chen Z, Zhang C, Wang J*, Kwok-Wing Tsui S*. Whole genome methylation array reveals the down-regulation of IGFBP6 and SATB2 by HIV-1. Sci Rep. 2015. 5:10806. PMID:26039376
44. Yang FC, Kuang WD, Li C, Sun WW, Qu D, Wang JH*. Toll-Interacting Protein Suppresses HIV-1 Long-Terminal-Repeat-Driven Gene Expression and Silences the Post-Integrational Transcription of Viral Proviral DNA. PLoS ONE, 2015; PMID:25915421
45. Ma L, Shen CJ, Cohen E, Xiong SD, Wang JH*. MiRNA-1236 inhibits HIV-1 infection of monocytes by repressing translation of cellular factor VprBP. PLoS ONE, 2014; PMID: 24932481.
46. Zhai RR, Jiang AP, Wang HB, Ma L, Ren XX, Jiang JF, Wu L, Wei JF*, Wang JH*. Histamine enhances HIV-1-induced modulation of dendritic cells to skew naïve T cell differentiation toward regulatory T cells. Virology, 2013; PMID 23652320.
47. Liu W, Qin Y, Bai L, Lan K, Wang JH*. Kaposi's-sarcoma -associated-herpesvirus -activated dendritic cells promote HIV-1 trans-infection and suppress CD4+ T cell proliferation. Virology, 2013; PMID23510674.
48. Qin Y, Li Y, Liu W, Tian R, Guo Q, Li S, Li H, Zhang D, Zheng Y, Wu L, Lan K*, Wang JH*. Penicillium marneffei-stimulated dendritic cells enhance HIV-1 trans-infection and promote viral infection by activating primary CD4+ T cells. PLoS One. 2011; PMID 22110688.
49. Qin Y, Li Y Y, Jiang A P, Jiang J F, Wang JH*. Stimulation of Cryptococcus neoformans isolated from skin lesion of AIDS patient matures dendritic cells and promotes HIV-1 trans-infection. Biochem Biophys Res Commun; 2012; PMID 22704932.
50. Tian RR, Guo HX, Wei JF, Yang CK, He SH*, Wang JH*. IFN-lambda inhibits HIV-1 integration and post-transcriptional events in vitro, but there is only limited in vivo repression of viral production. Antiviral Res. 2012; PMID: 22584351.
51. Ji H, Jiang Z, Lu P, Ma L, Li C, Pan H, Fu Z, Qu X, Wang P, Deng J, Yang X, Wang J, Zhu H.Specific Reactivation of Latent HIV-1 by dCas9-SunTag-VP64-mediated Guide RNA Targeting the HIV-1 Promoter.Mol Ther. 2016. PMID:26775808
52. Qu X, Wang P, Ding D, Li L, Wang H, Ma L, Zhou X, Liu S, Lin S, Wang X, Zhang G, Liu S, Liu L, Wang J, Zhang F, Lu D, Zhu H. Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells. Nucleic Acids Res, 2013; PMID: 23804764.
53. Ren XX, Ma L, Liu QW, Li C, Huang Z, Wu L, Xiong SD, Wang JH, Wang HB.The molecule of DC-SIGN captures enterovirus 71 and confers dendritic cell-mediated viral trans-infection. Virol J. 2014; PMID:24620896.
54. St Gelais C, Coleman CM, Wang JH, Wu L. HIV-1 Nef enhances dendritic cell-mediated viral transmission to CD4+ T cells and promotes T-cell activation. PLoS One. 2012; PMID: 22479639.
55. Zhang C, de Silva S, Wang JH, Wu L. Co-evolution of primate SAMHD1 and lentivirus Vpx leads to the loss of the vpx gene in HIV-1 ancestor. PLoS One. 2012; PMID: 22574228.
56. Li S K, Leung R K, Guo H X, Wei J F, Wang JH, Kwong K T, Lee S S, Zhang C, and Tsui S K. Detection and identification of plasma bacterial and viral elements in HIV/AIDS patients in comparison to healthy adults. Clin Microbiol Infect. 2012；PMID: 22084916.
57. Liu J, Chen K, Wang JH, and Zhang C. Molecular evolution of the primate antiviral restriction factor tetherin. PLoS One. 2010; PMID:20689591.
58. Guo D, Ding N, Xu Y, Guo H, Wei J F, Wang JH, He G, Yang R, and Zhang C. Near full-length genome characterization of an HIV-1 CRF01_AE strain in Jiangsu, China: evidence of two independent introductions from Fujian. AIDS Res Hum Retroviruses, 2009; PMID:19534629.
59. Wang JH, Kwas C, Wu L. Intercellular adhesion molecules (ICAM)-1, but not ICAM-2 and -3, is important for dendritic cell-mediated human immunodeficiency virus type 1 transmission. J. Virol. 2009;PMID: 19211748.
60. Wang JH, Wells C, Wu L. Macropinocytosis and cytoskeleton contribute to dendritic cell-mediated HIV-1 transmission to CD4+ T cells. Virology, 2008; PMID: 18804253.
61. Janas AM, Dong C, Wang JH, Wu L. Productive infection of human immunodeficiency virus type 1 in dendritic cells requires fusion-mediated viral entry. Virology, 2008; PMID: 18329684.
62. Dong C, Janas AM, Wang JH, Olson WJ, Wu L. Characterization of human immunodeficiency virus type 1 replication in immature and mature dendritic cells reveals dissociable cis- and trans-infection. J. Virol.2007; PMID: 17686876.
63. Wang JH, Janas AM, Olson WJ, Wu L. Functionally distinct transmission of human immunodeficiency virus type 1 mediated by immature and mature dendritic cells. J. Virol. 2007; PMID: 17567699.
64. Wang JH, Janas AM, Olson WJ, KewalRamani VN, Wu L. CD4 coexpression regulates DC-SIGN-mediated transmission of human immunodeficiency virus type 1. J. Virol. 2007; PMID: 17151103.
65. Wang JH, Kong J, Li W, Molchanova V, Chikalovets I, Belogortseva N, Luk'yanov P, Zheng YT. A beta-galactose-specific lectin isolated from the marine worm Chaetopterus variopedatus possesses anti-HIV-1 activity. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2006; PMID:16316787.
66. Wang JH, Tam SC, Huang H, Ouyang DY, Wang YY, and Zheng YT. Site-directed PEGylation of richosanthin retained its anti-HIV activity with reduced potency in vitro. Biochem. Biophys. Res. Commun. 2004; PMID:15094363.
67. Wang JH., Nie HL, Huang H, Tam SC, and Zheng YT. Independency of anti-HIV-1 activity from ribosome-inactivating activity of trichosanthin. Biochem. Biophys. Res. Commun. 2003; PMID:12593852.
68. Wang JH, Nie HL, Tam SC, Huang H, and Zheng YT. Anti-HIV-1 property of trichosanthin correlates with its ribosome inactivating activity. FEBS Lett. 2002; PMID: 12417329.
