王兰

王兰，女，教授，博士生导师。国家肺纤维化生物学过程及防控学科创新引智基地（111计划）秘书，河南省器官纤维化杰出外籍科学家工作室负责人，中国生物物理学会表型组分会委员，河南省生物化学与分子生物学学会副理事长，河南省药学会中药资源委员会委员，河南省药学会天然产物委员会委员，国际期刊《Fibrosis》副主编。主要从事肺纤维化生物标志物和甲状腺激素调控肺纤维化的代谢稳态研究。

2011年6月博士毕业于韩国江原大学医生命学院，获得生物医学博士学位。2006.10－2007.10间，作为访问学者到丹麦哥本哈根大学生命科学学院合作研究，2016.7－2017.7 在美国华盛顿州立大学药学院访问学者，主要从事端粒酶基因的表观遗传调控研究, 2017.12--2019.08，复旦大学生科院访问研究，主要从事多组学解析疾病机理研究。目前主持及参与国家重点研发专项、国家自然基金、河南省重点研发专项、河南省国际科技合作项目、国家虚拟仿真实验教学一流课程、河南省优质资源课-双语教学示范课等项目10余项，在Naturecommunications, Advanced Science,Theranostics等国际期刊发表学术论文80余篇，发明授权国家专利3项，受理5项，主编《肺纤维化小鼠模型构建，诊断及治疗》、参编《生物化学》等教材6部。

多组学解析疾病机理

肺纤维化生物标志物

甲状腺激素调控肺纤维化的代谢稳态

河南省生物化学与分子生物学学会副理事长

国际期刊《Fibrosis》副主编

中国生物物理学会表型组分会委员

河南省药学会中药资源委员会委员

河南省药学会天然产物委员会委员

1、甲状腺激素对肺纤维化的治疗作用与机理研究。国家重点研发计划任务负责人

2、基于S蛋白受体结合结构域（RBD）的新冠肺炎病毒疫苗研发及肺纤维化控制。高端外国专家引进计划新冠肺炎防控专项计划

3、肺纤维化治疗新药研发。河南省重点研发计划。第一参与人

4、肺纤维化新药GC-1研发。新乡市重大科技创新专项。第一参与人

5、器官纤维化杰出外籍科学家工作室。河南省外国专家项目。负责人

6、特发性肺纤维化诊断血清标志物的确立。河南省科技攻关项目，主持

7、多组学解析甲状腺激素调控肺纤维化的机制。河南省国际科技合作，主持

8、肺纤维化血清标志物的研发。横向合作。主持

9、植物源性抗菌肽生物活性研究。河南省重点科技攻关项目。主持

10、火炬树果实有效成分抑制结肠癌机理研究。河南省科技攻关项目。主持

11、肺纤维化小鼠模型构建、诊断及治疗虚拟仿真实验。国家级一流课程

12、《高级生物化学》河南省优质资源课双语教学示范课，负责人

代表性论文：

1. Bin Li, Cong Xia, Wanyu He, Jingyi Liu, Yanlin Zhou, Guoying Yu*, Lan Wang*. The Thyroid Hormone Analog GC-1Mitigates Acute Lung Injury by Inhibiting M1 Macrophage Polarization. AdvancedScience. 2024 https:// doi.10.1002/advs.202401931

2. Xin Pan, Lan Wang*, Juntang Yang, Yingge Li, Min Xu, Chenxi Liang, Lulu Liu, Zhongzheng Li,Cong Xia, Jiaojiao Pang, Mengyuan Wang, Meng li, Saiya Guo, Peishuo Yan, ChenDing, Ivan O. Rosas, Guoying Yu*. TRβ activation confers AT2-to-AT1 cell differentiation and anti-fibrosis during lung repair via KLF2 and CEBPA. Nature Communication. 2024. DOI : 10.1038/s41467-024-52827-z

3. Bin Li, Jingyi Liu,Wanyu He, Yanlin Zhou, Man Zhao, Cong Xia, Xiaoyue Pan, Zhihua Ji, RuoyuDuan, Hui Lian, Kai Xu, Guoying Yu, Lan Wang*. Inhibition of macrophage inflammasome assembly and pyroptosis with GC-1 ameliorates acute lung injury.Theranostics. 2025; 15(6): 2360-2374. doi: 10.7150/thno.101866.

4. Ruyan Wan, Siqi Long, Shuaichen Ma, Peishuo Yan, Zhongzheng Li, Kai Xu, Hui Lian, Wenwen Li, Yudi Duan, MiaomiaoZhu, Lan Wang* , Guoying Yu*.NR2F2 alleviates pulmonary fibrosis by inhibition of epithelial cell senescence. Respiratory Research (2024) 25:154.https://doi.org/10.1186/s12931-024-02777-3

5. Minglu Xu, Mengxia Zhao, Miaomiao Zhu, Hongmei Yuan, Zhongzheng Li, Peishuo Yan, Chi Ma, Huabin Zhao, ShenghuiWang, Ruyan Wan, Lan Wang*, Guoying Yu*.Hibiscus manihot L. flower extract induces anticancer activity through modulation of apoptosis and autophagy in A549 cells. Scientific Reports. (2024) 14:8102. https://doi.org/10.1038/s41598-024-58439-3

6. Peishuo Yan, Jingyi Liu, Zhenwei Li, Jiawei Wang, Zhao Zhu, LanWang*，Guoying Yu *. Glycolysis Reprogrammingin Idiopathic Pulmonary Fibrosis: Unveiling the Mystery of Lactate in the LungInt. J. Mol. Sci. 2024, 25, 315. https://doi.org/10.3390/ijms25010315

7. Peishuo Yan, Kun Yang, Mengwei Xu, Miaomiao Zhu, Yudi Duan, Wenwen Li, Lulu Liu, Chenxi Liang, Zhongzheng Li, XinPan, Lan Wang*, Guoying Yu*. CCT6A alleviates pulmonary fibrosis by inhibiting HIF-1α mediated lactate production. Journal of Molecular Cell Biology.2024,May

8. Lan Wang, Wenyu Zhao, Cong Xia, Shuaichen Ma, Zhongzheng Li, Ningdan Wang, Linke Ding, Yaxuan Wang, Lianhui Cheng, Huibing Liu, Juntang Yang, Yajun Li, Ivan Rosas, Guoying Yu*.TRIOBP modulates β‑catenin signaling by regulation of miR‑29b in idiopathic pulmonary fibrosis. Cellular and Molecular Life Sciences (2024) 81:13. https://doi.org/10.1007/s00018-023-05080-4

9. Lan Wang, Hongmei Yuan,Wenwen Li, Peishuo Yan, Mengxia Zhao, Zhongzheng Li, Huabin Zhao, ShenghuiWang, Ruyan Wan, Yajun Li, Juntang Yang, Xin Pan,Ivan Rosas, Guoying Yu*.ACSS3 regulates the metabolic homeostasis of epithelial cells and alleviates pulmonary fibrosis. BBA - Molecular Basis of Disease 1870 (2024)166960

10. Lan Wang; Zhongzheng Li; Ruyan Wan; Xin Pan; Bin Li; HuabinZhao; Juntang Yang; Weiming Zhao; Shenghui Wang; Qiwen Wang; Peishuo Yan; ChiMa; Hongmei Yuan; Ivan Rosas; Chen Ding; Baofa Sun; Guoying Yu*. Single-cell RNA-seq provides new insights into therapeutic roles of thyroid hormone in the idiopathic pulmonary fibrosis,Am J Respir Cell Mol Biol, 2023 Oct;69(4):456-469. doi:10.1165/rcmb.2023-0080OC

11. Lan Wang; Minghui Zhu; Yan Li; Peishuo Yan; Zhongzheng Li; Xiuping Chen; Juntang Yang; Xin Pan; Huabin Zhao; Shenghui Wang; Hongmei Yuan; Mengxia Zhao; Xiaogang Sun; Ruyan Wan; Fei Li; Xiaobo Wang; Hongtao Yu; IvanRosas; Chen Ding; GuoyingYu*. Serum proteomics identify biomarkers associated with the pathogenesis of idiopathic pulmonary fibrosis, Molecular & Cellular Proteomics, 2023, 22(4):1-13.doi: 10.1016/j.mcpro.2023.100524

12. Lan Wang;Wenyu Zhao; Cong Xia; Zhongzheng Li; Weiming Zhao; Kai Xu; Ningdan Wang; HuiLian; Ivan O. Rosas; Guoying Yu. TRIB3 mediates fibroblast activation and fibrosis though interaction with ATF4 in IPF, International Journal of Molecular Sciences, 2022, 23(24):1-17. doi: 10.3390/ijms232415705

13. Lan Wang, Kai Xu, Ningdan Wang, Linke Ding, Wenyu Zhao, Ruyan Wan,Weiming Zhao, Xiaoshu Guo, Xin Pan, Juntang Yang, Ivan Rosas and Guoying Yu*. Fenbendazole attenuates bleomycin-Induced pulmonary fibrosis in mice via suppression of fibroblast-to-myofibroblast differentiation. Int J Mol Sci. 2022 Nov 15;23(22):1-14. doi: 10.3390/ijms232214088

14. Yaxuan Wang, Lan Wang, Shuaichen Ma, Lianhui Cheng, Guoying Yu*. Repair and regeneration of the alveolar epithelium in lung injury.The FASEB journal, 2024;38(8), e23612. https://doi.org/10.1096/fj.202400088R

15. Ruyan Wan, Lan Wang, Miaomiao Zhu, Wenwen Li, Yudi Duan and Guoying Yu*. Cellular Senescence:A Troy Horse in Pulmonary Fibrosis. Int. J. Mol. Sci. 2023, 24(22), 16410; https://doi.org/10.3390/ijms242216410

16. Ruyan Wan, Lan Wang, Yudi Duan, Miaomiao Zhu, Wenwen Li, Mengxia Zhao, Hongmei Yuan, Kai Xu, Zhongzheng Li, Xiao Zhang, Guoying Yu*. ADRB2 inhibition combined with antioxidant treatment alleviates lung fibrosis by attenuating TGFβ/SMAD signaling in lung fibroblasts. Cell Death Discovery; doi:10.1038/s41420-023-01702-9

17. Caoyuan Niu, Kai Xu, Yanan Hu, Yanling Jia, YuexiaYang, Xiaoyue Pan, Ruyan Wan, Hui Lian, Qiwen Wang, Juntang Yang, Yajun Li,Ivan Rosas, Lan Wang* and GuoyingYu*.Tuftelin1 drives experimental pulmonary fibrosis progression by facilitating stress fiber assembly. Respiratory Research (2023) 24:318. https://doi.org/10.1186/s12931-023-02633

18. Zhongzheng Li, Liu Xin, Lan Wang, Huabin Zhao, Shenghui Wang, Guoying Yu, Depei Wu, Jianhong Chu, Jingjing Han. Integrated analysis of single-cell RNA-seq and bulk RNA-seqreveals RNA N6-methyladenosine modification associated with prognosis and drug resistance in acute myeloid leukemia. Front. Immunol. Volume 14 - 2023. doi:10.3389/fimmu.2023.1281687

19. Zhao H, Wang J, Li Z, Wang S, Yu G and Wang Lan* (2023) Identification ferroptosis-related hub genes and diagnostic model in Alzheimer’s disease. Frontiers in Molecular Neuroscience. 16:1280639.doi: 10.3389/fnmol.2023.1280639

20. Weiming Zhao; Lan Wang;Juntang Yang; Xinyu Chen; Xiaoshu Guo; Kai Xu; Ningdan Wang; Wenyu Zhao; CongXia; Hui Lian; Ivan Rosas; Guoying Yu*. Endothelial cell-derived MMP19 promotes pulmonary fibrosis by inducing E(nd)MT and monocyte infiltration, Cell Communication and Signaling, 2023, 21(56): 1-17. doi:10.1186/s12964-023-01040-4

21. Weiming Zhao; Lan Wang;Yaxuan Wang; Hongmei Yuan; Mengxia Zhao; Hui Lian; Shuaichen Ma; Kai Xu; Zhongzheng Li; Guoying Yu*. Injured Endothelial Cell: A Risk Factor for Pulmonary Fibrosis, International Journal of Molecular Sciences, 2023,24(10):8749-8766. doi: 10.3390/ijms24108749

22. Juntang Yang, Xin Pan, Min Xu,Yingge Li, Chenxi Liang, Lulu Liu, Zhongzheng Li, Lan Wang, Guoying Yu*.Down regulation of HMGCS2 mediated AECIIs lipid metabolic alteration promotes pulmonary fibrosis by activating fibroblasts. Respiratory research(2024),25(1), 176. https://doi.org/10.1186/s12931-024-02816-z

23. Juntang Yang; ChenxiLiang; Lulu Liu; Lan Wang; Guoying Yu*. High-Fat Diet RelatedLung Fibrosis-Epigenetic Regulation Matters, Biomolecules, 2023, 13(3):558-575.doi: 10.3390/biom13030558

24. Zhongzheng Li; ShenghuiWang; Huabin Zhao; Peishuo Yan; Hongmei Yuan; Mengxia Zhao; Ruyan Wan; Guoying Yu; Lan Wang*. Artificial neural network identified the significant genes to distinguish Idiopathic pulmonary fibrosis, Scientific Reports, 2023, 13(1):1-15. doi: 10.1038/s41598-023-28536-w

25. Lan Wang, Ruyan Wan, Xinyu Chen, Xiaoshu Guo, Zhongzheng Li, Weiming Zhao, Peishuo Yan, Guoying Yu*. Inhibition of MAD2L1 mediates pulmonary fibrosis through impairment of mitochondrial function and induction of cell senescence. Can Respir J. 2022 Oct 4;2022:1-13. doi:10.1155/2022/9663354

26. Lan Wang，Ming Lu Xu，Ling Xin，Chi Ma，Guoying Yu. Oxidative stress induced apoptosis mediated anticancer activity of Rhus typhina fruits extract in human colon cancer. Medicinal Chemistry Research 2019,28:917–925

27. Lan Wang, Ming Lu Xu, Jie Liu , You Wang , Jian HeHu, Myeong-Hyeon Wang. Sonchus asper extracti nhibits LPS-induced oxidative stress and pro-inflammatory cytokine productionin RAW264.7 macrophages. Nutrition Research and Practice, 2015;9(6):579-585

28. Wang Y, Gong W, ZhouH, Hu Y, Wang L, Shen Y, Yu Guoying, Cao J. A novel miRNA fromegg-derived exosomes of Schistosoma japonicum promotes liver fibrosis in murine schistosomiasis. Front. Immunol., 27 April 2022| https://doi.org/10.3389/fimmu.2022.860807.

29. Juntang Yang, Xin Pan, Lan Wang, Guoying Yu. Alveolar cells under mechanical stressed niche: critical contributors to pulmonary fibrosis. Mol Med (2020) 26:95

30. Xiaobo Wang, Minghui Zhu, Xiaoying Mo, Yiqiang Yuan, Xia Gao,Juntang Yang, Kai Xu, Pan Xin, Lan Wang, Guoying Yu. Practice and Reflection on the Ethical Review on Covid-19 Pandemic. Cancer Stud Ther J 5(2):1–4, 2020

31. Minghui Zhu, Ruyan Wan, Fei Li, Xiaobo Wang, Hongtao Yu, Lan Wang, Guoying Yu. Serum biomarkers in idiopathic pulmonary fibrosis. International Journal of Respiratory. 2020,12, (40),23,1801-1805

32. Yong-Chao Li, Lan Wang, Ben-zhai Hai and Ming-Lu Xu. Effect of Various Treatment Methods on the Bisphenol A Concentration in Edible Mushroom Segments during Cultivation. Advance Journal of Food Science and Technology 13(1): 40-48, 2017

33. Lan Wang, Ming Lu Xu, Jian He Hu,Søren K. Rasmussen, Myeong-Hyeon Wang. Codonopsis lanceolata extract induces G0/G1 arrest and apoptosis in human colon tumor HT-29 cells - Involvement of ROS generation and polyamine depletion. Food and Chemical Toxicology 2011, 49:149-154.

34. Lan Wang, Ming Lu Xu, Li Jie Guo , Lin Song Wang. Antioxidant activities and phenolic compounds of various extracts of Rhus typhina fruits and leaves. Advance Journal of Food Science and Technology 2015 ,7(4): 223-229.

35. Lan Wang, Hee Jeong Son, Ming-LuXu, Jian-He Hu, and Myeong-Hyeon Wang*. Anti-inflammatory and anticancer properties of dichloromethane and butanol fractions from the stem bark of Broussonetia papyrifera. Journal Korean Social Application Biology Chemistry 2010, 53(3):297-303.

36. Lan Wang, Ming Lu Xu, Søren K.Rasmussen, Myeong-Hyeon Wang*. Vomifoliol 9-O-α-arabinofuranosyl(1→6)-β-D-glucopyranoside from the leaves of Diospyros Kaki stimulates the glucose uptake in HepG2 and 3T3-L1cells. Carbohydrate Research. 2011, 346:1212-1216. 

37. Lan Wang, Gui-Fang Xu, Xiao-Xia Liu,Ai-Xia Chang, Ming-Lu Xu, Amal Kumar Ghimeray, Jing-Pei Piao and DongHa Cho*.In vitro antioxidant properties and induced G2/M arrest in HT-29 cells of dichloromethane fraction from Liriodendron tulipifera.  Journal of Medicinal Plants Research 2012, 6(3):424-432.

38. Ming-Lu Xu，Lan Wang, Gui-FangXu, Jian-He Hu, and Myeong-Hyeon Wang*. Antioxidant and anti-proliferative activities of different solvent fractions from methanol extracts of Sparganiun stoloniferum. Horticulture Environment and Biotechnology. 2010, 51(6):539-544.  

39. Li Wang, Lan Wang, Fang-JunLi, Lin-Song Wang*, and Myeong-Hyeon Wang Modulation of endogenous peroxidase by exogenous peroxidase in chinese red radish seedling. Hort. Environ.Biotechnol. 2011, 52(5):448-454.

40. Huan Liu, Lan Wang, and Myeong-Hyeon Wang*. Antioxidant and nitric oxide release inhibition activities of methanolic extract from Manyflower Glorybower. Horticulture, Environment, andBiotechnology. 2011, 52(3):1-6.

41. Ming-Lu Xu, Lan Wang, Jian-He Hu, Soek Ki Lee, and Myeong-Hyeon Wang*. Antioxidant activities and related polyphenolic constituents of the methanol extract fractions from Broussonetia papyrifera stem bark and wood. Food Sci. Biotechnol. 2010, 19(3):677-682.

42. Xiao Xia Liu, Lan Wang,Yu Jie Wang, Li Ling Cai. D-glucose Enhanced 5-Aminolevulinic Acid Productionin Recombinant Escherichia coli Culture. 2010, 160:822-830.

43. Ming-Lu Xu, Lan Wang, Jian-He Hu, Soek Ki Lee, and Myeong-Hyeon Wang*. Antioxidant activities andrelated polyphenolic constituents of the methanol extract fractions from Broussonetia papyrifera stem bark andwood. Food Sci. Biothechnol. 2010, 19(3):677-682.

44. Ming-Lu Xu, Lan Wang andMyeong-Hyeon Wang*. The Antioxidant and Anticancer Effects of MeOH Extract of Liriodendron tulipifera. Korean J. PlantRes. 2011, 24(1):23-29.

45. Ming-LuXu, Lan Wang, Gui-Fang Xu and Myeong-Hyeon Wang*. Antidiabetes and Angiotensin Converting Enzyme Inhibitory Activity of Sonchus asper (L) Hill Extract. Kor. J. Pharmacogn. 2011,42(1):61-67.

46. 朱明慧，万汝燕，李飞，王晓博，于洪涛，王兰，余国营。特发性肺纤维化血清生物指示物的研究。国际呼吸杂志2020年12月第40卷第23期，1801-05

47. 邢双涛，冯世杰，张一凡，王兰，余国营。不同运动方式对哮喘患儿肺功能影响的网状Meta分析.[J].学报(自然科学版),2023（02）

发明专利：

1. 王兰，李中正，赵华斌，王胜辉，余国营。特发性肺纤维化血浆蛋白标志物及其在制备检测试剂或诊断工具中的应用。ZL 2022 1 0506078.5，国家发明专利，2025

2.王兰，邱宗波，许明录，常爱霞，周春娥, 李建军。一种从火炬树果实中提取木犀草素和木犀草素-7-O-β-D-吡喃葡萄糖苷的方法。ZL201510050991.9，国家发明专利，2017

3. 王兰，潘新，余国营。甲状腺激素通路活化剂抗肺纤维化的应用。202311399981.7

4. 王兰，余国营。特发性肺纤维化疾病血液诊断标志物 CBRI 及其在制备诊断或预后工具中的应用, 2020-11-05, 中国, 202011218094.1 (专利)

5.王兰，闫培硕，余国营。特发性肺纤维化疾病诊断标志物 CCT6A 及其制备诊断或预后工具中的应用,2020-11-5, 中国, 202011218095.6 (专利)

6.王兰，余国营。特发性肺纤维化疾病诊断标志物及其制备诊断或预后工具中的应用, 2019-12-13, 中国, 201911277110.1 (专利)

著作：

1.《肺纤维化小鼠模型构建、诊断及治疗》数字化教材，高等教育出版社，主编，2022

2.《动物源性抗菌肽》，科学出版社，副主编，2015年

3.《基因工程》，科学出版社，参编，2012年

4.《生物化学》，科学出版社，参编，2011，2016年

5.《生物化学习题集》，科学出版社，参编，2012年